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The Effect of Loading Rate on the Measurement of Cellular Viscoelasticity Properties with Atomic Force Microscopy
Wang B(王博); Wang WX(王文学); Wang YC(王越超); Liu B(刘斌); Liu LQ(刘连庆)
Department机器人学研究室
Conference Name2017 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)
Conference DateAugest 7-11, 2017
Conference PlaceShanghai, CHINA
Author of SourceNatl Nat Sci Fdn China, Minist Sci & Technol Peoples Republic of China, Minist Educ Peoples Republic of China, European Commiss, Res Execut Agcy, Jilin Provincial Sci & Technol Dept, IFToMM, Int Soc Nanomfg
Source Publication2017 IEEE INTERNATIONAL CONFERENCE ON MANIPULATION, MANUFACTURING AND MEASUREMENT ON THE NANOSCALE (3M-NANO)
PublisherIEEE
Publication PlaceNEW YORK
2017
Pages246-249
Indexed ByEI ; CPCI(ISTP)
EI Accession number20182205249905
WOS IDWOS:000426927300052
Contribution Rank1
ISSN2373-5422
ISBN978-1-5386-1081-7
KeywordSingle Cell Dynamic Model Mechanical Properties Loading Rate Viscoelasticity Atomic Force Microscope
Abstract

Organisms are composed by cells, and the cells can also reflect the physiology of creatures. The composition of a single cell and its cytoskeletal structure can be reflected by the mechanical properties of the cell. The cellular mechanical properties are correlated to the biological functions of the cell and its physiological activities. Therefore, establishing the mathematical model for the mechanical properties of single cells could provide the foundation for analyzing and regulating the physiological state of cells. In our previous work, we established a dynamical mathematical model with the viscose and elastic properties of single cells as the system parameters of the cellular system. The mathematical model can characterize the stress-relaxation phenomenon of a single cell, which is caused by an atomic force microscope (AFM). However, in this model, the effect of the loading rate of the AFM cantilever was neglected and all the stress-relaxation curves needed to be measured at a constant loading rate, in case that different loading rates would cause errors in the stress-relaxation curves. In this study, we discussed the effect of the loading rate on the measurement of cellular viscoelasticity properties with AFM. We clearly illustrated that the cellular stress-relaxation curves won't be effected by the loading rate of AFM when the loading rate is higher than a threshold. The stress-relaxation curves with the loading rate which is higher than the threshold can be used to extract viscoelasticity parameters more accurately.

Language英语
Citation statistics
Document Type会议论文
Identifierhttp://ir.sia.cn/handle/173321/21653
Collection机器人学研究室
Corresponding AuthorWang WX(王文学); Liu LQ(刘连庆)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences
2.University of Chinese Academy of Sciences, Beijing
Recommended Citation
GB/T 7714
Wang B,Wang WX,Wang YC,et al. The Effect of Loading Rate on the Measurement of Cellular Viscoelasticity Properties with Atomic Force Microscopy[C]//Natl Nat Sci Fdn China, Minist Sci & Technol Peoples Republic of China, Minist Educ Peoples Republic of China, European Commiss, Res Execut Agcy, Jilin Provincial Sci & Technol Dept, IFToMM, Int Soc Nanomfg. NEW YORK:IEEE,2017:246-249.
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