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Detecting the Micro/nano Physical Properties of Single Lymphoma Cells with Atomic Force Microscopy
Liu B(刘斌); Wei FN(魏发南); Li M(李密); Wang B(王博); Liu LQ(刘连庆)
作者部门机器人学研究室
会议名称2017 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)
会议日期Augest 7-11, 2017
会议地点Shanghai, CHINA
会议主办者Natl Nat Sci Fdn China, Minist Sci & Technol Peoples Republic of China, Minist Educ Peoples Republic of China, European Commiss, Res Execut Agcy, Jilin Provincial Sci & Technol Dept, IFToMM, Int Soc Nanomfg
会议录名称2017 IEEE INTERNATIONAL CONFERENCE ON MANIPULATION, MANUFACTURING AND MEASUREMENT ON THE NANOSCALE (3M-NANO)
出版者IEEE
出版地NEW YORK
2017
页码250-253
收录类别EI ; CPCI(ISTP)
EI收录号20182205243257
WOS记录号WOS:000426927300053
产权排序1
ISSN号2373-5422
ISBN号978-1-5386-1081-7
关键词Atomic Force Microscopy Lymphoma Image Elasticity Force Curve
摘要

Non-Hodgkin's lymphoma (NHL) is the most common adult hematological cancer. With the advent of combination therapy of chemotherapy and the monoclonal anti-CD20 antibody Rituximab, the substantial advancement in the treatment of B-cell malignancies has been achieved. In the clinical treatment of NHL, however, there are still many patients who are not sensitive to the therapy of rituximab. Hence investigating the interactions between rituximab and lymphoma cells is crucial for us to understand the actions of rituximab and design drugs with better efficacies. Traditional biochemical methods for cell detection require the various pretreatments of the cell, destroying the structures of cells. This paper uses atomic force microscopy (AFM) to label-free characterize the micro/nano physical properties of single lymphoma cells, including cell morphology, cell elasticity, and molecular interactions on the cell surface. The study improved our understanding of the rituximab actions.

语种英语
引用统计
文献类型会议论文
条目标识符http://ir.sia.cn/handle/173321/21654
专题机器人学研究室
通讯作者Liu B(刘斌)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences
2.School of Mechanical Engineering and Automation, Fuzhou University
推荐引用方式
GB/T 7714
Liu B,Wei FN,Li M,et al. Detecting the Micro/nano Physical Properties of Single Lymphoma Cells with Atomic Force Microscopy[C]//Natl Nat Sci Fdn China, Minist Sci & Technol Peoples Republic of China, Minist Educ Peoples Republic of China, European Commiss, Res Execut Agcy, Jilin Provincial Sci & Technol Dept, IFToMM, Int Soc Nanomfg. NEW YORK:IEEE,2017:250-253.
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