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A Review of Nanoscale Characterizing Individual DNA Behaviors Using Atomic Force Microscopy
Li M(李密)1; Dang D(党丹)2; Xi N(席宁)1,3; Wang YC(王越超)1; Liu LQ(刘连庆)1
Department机器人学研究室
Source PublicationIEEE TRANSACTIONS ON NANOTECHNOLOGY
ISSN1536-125X
2018
Volume17Issue:5Pages:920-933
Indexed BySCI ; EI ; CPCI(ISTP)
EI Accession number20181404982776
WOS IDWOS:000443975800008
Contribution Rank1
Funding OrganizationNational Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; CAS FEA International Partnership Program for Creative Research Teams
KeywordAtomic Force Microscopy Nanoscale Dna Topography Dna Mechanics Dna Origami Nanorobotics
Abstract

Deoxyribonucleic acid (DNA), the structural basis of genetics, plays a crucial role in the life of cells. The abnormal behaviors of DNA are closely related to the pathological changes of living organisms. The advent of atomic forcemicroscopy (AFM) provides an exciting instrument for biophysically probing the nanoscale dynamic activities of the individual native molecules, considerably complementing the results obtained by traditional biochemical population-averaged measurements. In the past decades, AFM has been widely used in DNA studies, significantly providing novel insights into molecular biology. In this paper, the methodologies and progresses of utilizing AFM to characterize the behaviors of individual DNA molecules from several facets (including DNA topography imaging, DNA mechanics measurements, DNA origami, and DNA nanorobotics) are reviewed, and the future directions are discussed.

Language英语
WOS SubjectEngineering, Electrical & Electronic ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS KeywordIi Restriction Endonucleases ; Nucleotide Excision-repair ; Single-molecule Force ; Plasmid Dna ; Persistence Length ; Magnetic Tweezers ; Protein Complexes ; Optical Tweezers ; Delivery-system ; Mismatch Repair
WOS Research AreaEngineering ; Science & Technology - Other Topics ; Materials Science ; Physics
Funding ProjectNational Natural Science Foundation of China[61503372] ; National Natural Science Foundation of China[61522312] ; National Natural Science Foundation of China[U1613220] ; National Natural Science Foundation of China[61433017] ; National Natural Science Foundation of China[61504072] ; Youth Innovation Promotion Association CAS[2017243] ; CAS FEA International Partnership Program for Creative Research Teams
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/21730
Collection机器人学研究室
Corresponding AuthorLi M(李密)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Shenyang 110016, China
2.School of Medical Devices, Shenyang Pharmaceutical University, Shenyang 110016, China
3.Department of Industrial and Manufacturing Systems Engineering, The University of Hong Kong, Hong Kong, China
Recommended Citation
GB/T 7714
Li M,Dang D,Xi N,et al. A Review of Nanoscale Characterizing Individual DNA Behaviors Using Atomic Force Microscopy[J]. IEEE TRANSACTIONS ON NANOTECHNOLOGY,2018,17(5):920-933.
APA Li M,Dang D,Xi N,Wang YC,&Liu LQ.(2018).A Review of Nanoscale Characterizing Individual DNA Behaviors Using Atomic Force Microscopy.IEEE TRANSACTIONS ON NANOTECHNOLOGY,17(5),920-933.
MLA Li M,et al."A Review of Nanoscale Characterizing Individual DNA Behaviors Using Atomic Force Microscopy".IEEE TRANSACTIONS ON NANOTECHNOLOGY 17.5(2018):920-933.
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