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题名:
Visible light induced electropolymerization of suspended hydrogel bioscaffolds in a microfluidic chip
作者: Li P(李盼); Yu HB(于海波); Liu N(刘娜); Wang FF(王飞飞); Lee, Gwo-Bin; Wang YC(王越超); Liu LQ(刘连庆); Li WJ(李文荣)
作者部门: 机器人学研究室
通讯作者: Liu LQ(刘连庆) ; Li WJ(李文荣)
刊名: Biomaterials Science
ISSN号: 2047-4830
出版日期: 2018
卷号: 6, 期号:6, 页码:1371-1378
收录类别: SCI ; EI
EI收录号: 20182305268018
WOS记录号: WOS:000433604100007
产权排序: 1
项目资助者: National Natural Science Foundation of China (Project No. 61475183, 61433017, 61503258 and U1613220), the NSFC/RGC Joint Research Scheme (Project No. 51461165501 and N_CityU132/14), the Hong Kong Research Grants Council (Project No. 9041928), the CAS FEA International Partnership Program for Creative Research Teams, and the Youth Innovation Promotion Association CAS.
摘要: The development of microengineered hydrogels co-cultured with cells in vitro could advance in vivo bio-systems in both structural complexity and functional hierarchy, which holds great promise for applications in regenerative tissues or organs, drug discovery and screening, and bio-sensors or bio-actuators. Traditional hydrogel microfabrication technologies such as ultraviolet (UV) laser or multiphoton laser stereolithography and three-dimensional (3D) printing systems have advanced the development of 3D hydrogel micro-structures but need either expensive and complex equipment, or harsh material selection with limited photoinitiators. Herein, we propose a simple and flexible hydrogel microfabrication method based on a ubiquitous visible-light projection system combined with a custom-designed photosensitive microfluidic chip, to rapidly (typically several to tens of seconds) fabricate various two-dimensional (2D) hydrogel patterns and 3D hydrogel constructs. A theoretical layer-by-layer model that involves continuous polymerizing-delaminating-polymerizing cycles is presented to explain the polymerization and structural formation mechanism of hydrogels. A large area of hydrogel patterns was efficiently fabricated without the usage of costly laser systems or photoinitiators, i.e., a stereoscopic mesh-like hydrogel network with intersecting hydrogel micro-belts was fabricated via a series of dynamic-changing digital light projections. The pores and gaps of the hydrogel network are tunable, which facilitates the supply of nutrients and discharge of waste in the construction of 3D thick bio-models. Cell co-culture experiments showed the effective regulation of cell spreading by hydrogel scaffolds fabricated by the new method presented here. This visible light enabled hydrogel microfabrication method may provide new prospects for designing cell-based units for advanced biomedical studies, e.g., for 3D bio-models or bio-actuators in the future.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sia.cn/handle/173321/21869
Appears in Collections:机器人学研究室_期刊论文

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作者单位: 1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.University of Chinese Academy of Sciences, Beijing 100000, China
3.School of Mechatronics Engineering and Automation, Shanghai University, Shanghai 200072, China
4.Department of Chemistry, Stanford University, Stanford CA
5.94305, United States
6.Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan
7.Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong

Recommended Citation:
Li P,Yu HB,Liu N,et al. Visible light induced electropolymerization of suspended hydrogel bioscaffolds in a microfluidic chip[J]. Biomaterials Science,2018,6(6):1371-1378.
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