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Visible light induced electropolymerization of suspended hydrogel bioscaffolds in a microfluidic chip
Li P(李盼)1,2; Yu HB(于海波)1; Liu N(刘娜)3; Wang FF(王飞飞)4; Lee, Gwo-Bin5; Wang YC(王越超)1; Liu LQ(刘连庆)1; Li WJ(李文荣)6
作者部门机器人学研究室
发表期刊Biomaterials Science
ISSN2047-4830
2018
卷号6期号:6页码:1371-1378
收录类别SCI ; EI
EI收录号20182305268018
WOS记录号WOS:000433604100007
产权排序1
资助机构National Natural Science Foundation of China ; NSFC/RGC Joint Research Scheme ; Hong Kong Research Grants Council ; CAS FEA International Partnership Program for Creative Research Teams ; Youth Innovation Promotion Association CAS
摘要

The development of microengineered hydrogels co-cultured with cells in vitro could advance in vivo bio-systems in both structural complexity and functional hierarchy, which holds great promise for applications in regenerative tissues or organs, drug discovery and screening, and bio-sensors or bio-actuators. Traditional hydrogel microfabrication technologies such as ultraviolet (UV) laser or multiphoton laser stereolithography and three-dimensional (3D) printing systems have advanced the development of 3D hydrogel micro-structures but need either expensive and complex equipment, or harsh material selection with limited photoinitiators. Herein, we propose a simple and flexible hydrogel microfabrication method based on a ubiquitous visible-light projection system combined with a custom-designed photosensitive microfluidic chip, to rapidly (typically several to tens of seconds) fabricate various two-dimensional (2D) hydrogel patterns and 3D hydrogel constructs. A theoretical layer-by-layer model that involves continuous polymerizing-delaminating-polymerizing cycles is presented to explain the polymerization and structural formation mechanism of hydrogels. A large area of hydrogel patterns was efficiently fabricated without the usage of costly laser systems or photoinitiators, i.e., a stereoscopic mesh-like hydrogel network with intersecting hydrogel micro-belts was fabricated via a series of dynamic-changing digital light projections. The pores and gaps of the hydrogel network are tunable, which facilitates the supply of nutrients and discharge of waste in the construction of 3D thick bio-models. Cell co-culture experiments showed the effective regulation of cell spreading by hydrogel scaffolds fabricated by the new method presented here. This visible light enabled hydrogel microfabrication method may provide new prospects for designing cell-based units for advanced biomedical studies, e.g., for 3D bio-models or bio-actuators in the future.

语种英语
WOS类目Materials Science, Biomaterials
关键词[WOS]ORGANS-ON-CHIPS ; CELL-CULTURE ; WATER ELECTROLYSIS ; DRUG DISCOVERY ; 3D ; TISSUE ; STEREOLITHOGRAPHY ; MICROFABRICATION ; FABRICATION ; GROWTH
WOS研究方向Materials Science
资助项目National Natural Science Foundation of China[61475183] ; National Natural Science Foundation of China[61433017] ; National Natural Science Foundation of China[61503258] ; National Natural Science Foundation of China[U1613220] ; NSFC/RGC Joint Research Scheme[51461165501] ; NSFC/RGC Joint Research Scheme[N_CityU132/14] ; Hong Kong Research Grants Council[9041928] ; CAS FEA International Partnership Program for Creative Research Teams ; Youth Innovation Promotion Association CAS[2015160]
引用统计
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/21892
专题机器人学研究室
通讯作者Liu LQ(刘连庆); Li WJ(李文荣)
作者单位1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China;
2.University of Chinese Academy of Sciences, Beijing 100000, China;
3.School of Mechatronics Engineering and Automation, Shanghai University, Shanghai 200072, China;
4.Department of Chemistry, Stanford University, Stanford CA 94305, United States;
5.Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan;
6.Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong
推荐引用方式
GB/T 7714
Li P,Yu HB,Liu N,et al. Visible light induced electropolymerization of suspended hydrogel bioscaffolds in a microfluidic chip[J]. Biomaterials Science,2018,6(6):1371-1378.
APA Li P.,Yu HB.,Liu N.,Wang FF.,Lee, Gwo-Bin.,...&Li WJ.(2018).Visible light induced electropolymerization of suspended hydrogel bioscaffolds in a microfluidic chip.Biomaterials Science,6(6),1371-1378.
MLA Li P,et al."Visible light induced electropolymerization of suspended hydrogel bioscaffolds in a microfluidic chip".Biomaterials Science 6.6(2018):1371-1378.
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