SIA OpenIR  > 机器人学研究室
A novel pyramidal cell type promotes sharp-wave synchronization in the hippocampus
Hunt, David L.1; Linaro, Daniele1,2; Si BL(斯白露)1,3; Romani, Sandro1; Spruston, Nelson1
Department机器人学研究室
Source PublicationNATURE NEUROSCIENCE
ISSN1097-6256
2018
Volume21Issue:7Pages:985–995
Indexed BySCI
WOS IDWOS:000437983900011
Contribution Rank3
Funding OrganizationHoward Hughes Medical Institute
Abstract

To support cognitive function, the CA3 region of the hippocampus performs computations involving attractor dynamics. Understanding how cellular and ensemble activities of CA3 neurons enable computation is critical for elucidating the neural correlates of cognition. Here we show that CA3 comprises not only classically described pyramid cells with thorny excrescences, but also includes previously unidentified 'athorny' pyramid cells that lack mossy-fiber input. Moreover, the two neuron types have distinct morphological and physiological phenotypes and are differentially modulated by acetylcholine. To understand the contribution of these athorny pyramid neurons to circuit function, we measured cell-type-specific firing patterns during sharp-wave synchronization events in vivo and recapitulated these dynamics with an attractor network model comprising two principal cell types. Our data and simulations reveal a key role for athorny cell bursting in the initiation of sharp waves: transient network attractor states that signify the execution of pattern completion computations vital to cognitive function.

Language英语
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/22147
Collection机器人学研究室
Corresponding AuthorHunt, David L.; Spruston, Nelson
Affiliation1.Janelia Research Campus Howard Hughes Medical Institute, Ashburn, VA, USA
2.VIB Center for Brain & Disease Research, Department of Neurosciences, KU Leuven, Leuven, Belgium
3.Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
Recommended Citation
GB/T 7714
Hunt, David L.,Linaro, Daniele,Si BL,et al. A novel pyramidal cell type promotes sharp-wave synchronization in the hippocampus[J]. NATURE NEUROSCIENCE,2018,21(7):985–995.
APA Hunt, David L.,Linaro, Daniele,Si BL,Romani, Sandro,&Spruston, Nelson.(2018).A novel pyramidal cell type promotes sharp-wave synchronization in the hippocampus.NATURE NEUROSCIENCE,21(7),985–995.
MLA Hunt, David L.,et al."A novel pyramidal cell type promotes sharp-wave synchronization in the hippocampus".NATURE NEUROSCIENCE 21.7(2018):985–995.
Files in This Item: Download All
File Name/Size DocType Version Access License
A novel pyramidal ce(4758KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hunt, David L.]'s Articles
[Linaro, Daniele]'s Articles
[Si BL(斯白露)]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hunt, David L.]'s Articles
[Linaro, Daniele]'s Articles
[Si BL(斯白露)]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hunt, David L.]'s Articles
[Linaro, Daniele]'s Articles
[Si BL(斯白露)]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: A novel pyramidal cell type promotes sharp-wave synchronization in the hippocampus.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.