SIA OpenIR  > 机器人学研究室
A novel pyramidal cell type promotes sharp-wave synchronization in the hippocampus
Hunt, David L.1; Linaro, Daniele1,2; Si BL(斯白露)1,3; Romani, Sandro1; Spruston, Nelson1
作者部门机器人学研究室
发表期刊NATURE NEUROSCIENCE
ISSN1097-6256
2018
卷号21期号:7页码:985–995
收录类别SCI
WOS记录号WOS:000437983900011
产权排序3
资助机构Howard Hughes Medical Institute
摘要

To support cognitive function, the CA3 region of the hippocampus performs computations involving attractor dynamics. Understanding how cellular and ensemble activities of CA3 neurons enable computation is critical for elucidating the neural correlates of cognition. Here we show that CA3 comprises not only classically described pyramid cells with thorny excrescences, but also includes previously unidentified 'athorny' pyramid cells that lack mossy-fiber input. Moreover, the two neuron types have distinct morphological and physiological phenotypes and are differentially modulated by acetylcholine. To understand the contribution of these athorny pyramid neurons to circuit function, we measured cell-type-specific firing patterns during sharp-wave synchronization events in vivo and recapitulated these dynamics with an attractor network model comprising two principal cell types. Our data and simulations reveal a key role for athorny cell bursting in the initiation of sharp waves: transient network attractor states that signify the execution of pattern completion computations vital to cognitive function.

语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/22147
专题机器人学研究室
通讯作者Hunt, David L.; Spruston, Nelson
作者单位1.Janelia Research Campus Howard Hughes Medical Institute, Ashburn, VA, USA
2.VIB Center for Brain & Disease Research, Department of Neurosciences, KU Leuven, Leuven, Belgium
3.Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
推荐引用方式
GB/T 7714
Hunt, David L.,Linaro, Daniele,Si BL,et al. A novel pyramidal cell type promotes sharp-wave synchronization in the hippocampus[J]. NATURE NEUROSCIENCE,2018,21(7):985–995.
APA Hunt, David L.,Linaro, Daniele,Si BL,Romani, Sandro,&Spruston, Nelson.(2018).A novel pyramidal cell type promotes sharp-wave synchronization in the hippocampus.NATURE NEUROSCIENCE,21(7),985–995.
MLA Hunt, David L.,et al."A novel pyramidal cell type promotes sharp-wave synchronization in the hippocampus".NATURE NEUROSCIENCE 21.7(2018):985–995.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
A novel pyramidal ce(4758KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Hunt, David L.]的文章
[Linaro, Daniele]的文章
[Si BL(斯白露)]的文章
百度学术
百度学术中相似的文章
[Hunt, David L.]的文章
[Linaro, Daniele]的文章
[Si BL(斯白露)]的文章
必应学术
必应学术中相似的文章
[Hunt, David L.]的文章
[Linaro, Daniele]的文章
[Si BL(斯白露)]的文章
相关权益政策
暂无数据
收藏/分享
文件名: A novel pyramidal cell type promotes sharp-wave synchronization in the hippocampus.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。