SIA OpenIR  > 空间自动化技术研究室
Effects of Lunar Soil Simulant on Systemic Oxidative Stress and Immune Response in Acute Rat Lung Injury
Sun Y(孙燕)1,2; Liu JG(刘金国)2; Kong, Yidi1; Hu, Jiasen1; Zhang, Xiaoping3
作者部门空间自动化技术研究室
关键词Lunar soil simulant acute injury inflammation immune response oxidative stress reaction
发表期刊INTERNATIONAL JOURNAL OF PHARMACOLOGY
ISSN1811-7775
2018
卷号14期号:6页码:766-772
收录类别SCI
WOS记录号WOS:000438908200003
产权排序1
资助机构Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department [20170520437] ; Undergraduate project of Shenyang Medical College [20179026] ; National Science Foundation of China [51775541] ; Science and Technology Development Fund (FDCT) of Macau [039/2013/A2, 020/2014/A1] ; Open Projects Funding of Lunar and Planetary Science Laboratory, MUST-Partner Laboratory of Key Laboratory of Lunar and Deep Space Exploration, CAS (Macau FDCT) [119/2017/A3]
摘要Background and Objective: Lunar dust is a kind of fine particles exists on the surface of the moon and it has become one of the most important challenges in future space missions. Lunar dust is toxic but the understanding of lunar dust toxicity is very poor. The aim of this study was to investigate the acute lung injury induced by lunar soil simulant and the mechanism of toxicity. Materials and Methods: Wistar rats were randomly divided into four groups including saline control group (tracheal perfusion in a 1 mL volume), two Chinese Academy of Sciences-1(CAS-1) lunar soil simulant groups (tracheal perfusion with 7 and 0.7 mg, respectively in a 1 mL volume) and PM2.5 group (tracheal perfusion with 0.7 mg in a 1 mL volume). The levels of tumor necrosis factor alpha, interleukin 6, immunoglobulin A and immunoglobulin G in the bronchoalveolar lavage fluid were examined and the changes of malondialdehyde, glutathione peroxidase and superoxide dismutase in the lung tissue were later measured after 4 and 24 h. Results:The determination of the cytokines, immunoglobulin and the oxidative stress index in lung tissue showed that the significant immune and oxidative stress response in the respiratory system were caused by lunar soil simulant and the immune and oxidative stress response promoted each other, resulting in toxic effect on pulmonary parenchymal cells and membrane of rats. Conclusion: The overall results showed that the immune response and oxidative stress reaction induced by lunar soil simulant were significant in the respiratory system. They promote each other, so as to cause the toxic effects on the lung parenchyma cells and membrane tissues of rats.
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.sia.cn/handle/173321/22308
专题空间自动化技术研究室
通讯作者Sun Y(孙燕)
作者单位1.Shenyang Medical College, 110034 Shenyang, China
2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, 110016 Shenyang, China
3.Lunar and Planetary Science Laboratory, Macau University of Science and Technology, 519020 Macau, China
推荐引用方式
GB/T 7714
Sun Y,Liu JG,Kong, Yidi,et al. Effects of Lunar Soil Simulant on Systemic Oxidative Stress and Immune Response in Acute Rat Lung Injury[J]. INTERNATIONAL JOURNAL OF PHARMACOLOGY,2018,14(6):766-772.
APA Sun Y,Liu JG,Kong, Yidi,Hu, Jiasen,&Zhang, Xiaoping.(2018).Effects of Lunar Soil Simulant on Systemic Oxidative Stress and Immune Response in Acute Rat Lung Injury.INTERNATIONAL JOURNAL OF PHARMACOLOGY,14(6),766-772.
MLA Sun Y,et al."Effects of Lunar Soil Simulant on Systemic Oxidative Stress and Immune Response in Acute Rat Lung Injury".INTERNATIONAL JOURNAL OF PHARMACOLOGY 14.6(2018):766-772.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Effects of Lunar Soi(477KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Sun Y(孙燕)]的文章
[Liu JG(刘金国)]的文章
[Kong, Yidi]的文章
百度学术
百度学术中相似的文章
[Sun Y(孙燕)]的文章
[Liu JG(刘金国)]的文章
[Kong, Yidi]的文章
必应学术
必应学术中相似的文章
[Sun Y(孙燕)]的文章
[Liu JG(刘金国)]的文章
[Kong, Yidi]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Effects of Lunar Soil Simulant on Systemic Oxidative Stress and Immune Response in Acute Rat Lung Injury.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。