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Differentiation of C2C12 Myoblasts and Characterization of Electro-Responsive Beating Behavior of Myotubes Using Circularly Distributed Multiple Electrodes for Bio-syncretic Robot
Zhang C(张闯)1,2; Wang WX(王文学)1; Xi N(席宁)3; Wang YC(王越超)1; Liu LQ(刘连庆)1
作者部门机器人学研究室
会议名称IEEE International Conference on Robotics and Automation (ICRA)
会议日期May 21-25, 2018
会议地点Brisbane, AUSTRALIA
会议主办者IEEE, CSIRO, Australian Govt, Dept Def Sci & Technol, DJI, Queensland Univ Technol, Woodside, Baidu, Bosch, Houston Mechatron, Kinova Robot, KUKA, Hit Robot Grp, Honda Res Inst, iRobot, Mathworks, NuTonomy, Ouster, Uber
会议录名称2018 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA)
出版者IEEE Computer Society
出版地LOS ALAMITOS, CA
2018
页码158-163
收录类别CPCI(ISTP)
WOS记录号WOS:000446394500017
产权排序1
ISSN号1050-4729
ISBN号978-1-5386-3081-5
摘要Micro-robots have a great application prospect in the biomedical field due to the feature of small size. To solve the issues of energy supply and bio-compatibility of micro-robots, bio-syncretic micro-robots composed of biological materials and electromechanical systems have been studied widely. The skeletal muscle is a potential material to develop bio-actuator for the bio-syncretic robots on account of the great contraction force and the controllability. However, the low differentiation quality of C2C12s and the control of the bio-syncretic robots are the two of the main challenges for the development of the bio-syncretic robots based on the skeleton muscle. In this paper, an approach based on circularly distributed multiple electrodes (CDMEs) was proposed to improve the differentiation of C2C12 myoblast cells and characterize the electro-responsive heating behavior of myotubes for the development of bio-syncretic robots. Three groups of C2C12 blasts were used to fulfill the differentiation experiments without electrical stimulation and with electrical stimulation using parallel electrodes and CDMEs respectively, for evaluating the effect of CDMEs on C2C12 differentiation. It was demonstrated that electrical field through CDMEs can improve the differentiation quality of C2C12 blasts into myotubes in terms of intensity, length, and widths. Then, the effect of electrical stimulation on the heating behaviors of myotubes was also investigated with CDMEs, and it was shown that the beating amplitudes of myotubes were significantly affected by the frequencies, amplitude and direction of electrical stimulation with respect to the myotubes, which is fundamental for the control of the micro-robot based on skeletal muscle cells. The proposed approach is useful for not only the development of the bio-syncretic robots, but also the study of muscle tissue engineering.
语种英语
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文献类型会议论文
条目标识符http://ir.sia.cn/handle/173321/23429
专题机器人学研究室
通讯作者Wang WX(王文学); Liu LQ(刘连庆)
作者单位1.State Key Laboratory of Robotics,Shenyang Institute of Automation, Chinese Academy of Science, Shenyang
2.University of Chinese Academy of Sciences, Beijing
3.Emerging Technologies Institute, Department of Industrial & Manufacturing Systems Engineering, University of Hong Kong
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Zhang C,Wang WX,Xi N,et al. Differentiation of C2C12 Myoblasts and Characterization of Electro-Responsive Beating Behavior of Myotubes Using Circularly Distributed Multiple Electrodes for Bio-syncretic Robot[C]//IEEE, CSIRO, Australian Govt, Dept Def Sci & Technol, DJI, Queensland Univ Technol, Woodside, Baidu, Bosch, Houston Mechatron, Kinova Robot, KUKA, Hit Robot Grp, Honda Res Inst, iRobot, Mathworks, NuTonomy, Ouster, Uber. LOS ALAMITOS, CA:IEEE Computer Society,2018:158-163.
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