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Atomic force microscopy in probing tumor physics for nanomedicine
Li M(李密)1,2; Xi N(席宁)3; Wang YC(王越超)1,2; Liu LQ(刘连庆)1,2
Department机器人学研究室
Source PublicationIEEE Transactions on Nanotechnology
ISSN1536-125X
2019
Volume18Pages:83-113
Indexed BySCI ; EI
EI Accession number20184906208046
WOS IDWOS:000455709300011
Contribution Rank1
Funding OrganizationNational Natural Science Foundation of China ; Youth Innovation Promotion Association ; CAS FEA International Partnership Program for Creative Research Teams
Keywordatomic force microscopy physical oncology nanomedicine cell mechanics molecular recognition tissue characterization
AbstractInvestigating the physics in tumor development and progression has been recognized as a promising way to advance both basic cancer research and clinical cancer treatment. The advent of atomic force microscopy (AFM) provides an exciting multifunctional tool for investigating the physical properties of biological systems under aqueous conditions with unprecedented spatiotemporal resolution, opening new possibilities for nanomedicine in physical oncology. In this article, the biomedical applications of AFM to investigate the physical sciences in oncology at single-cell, single-molecule, and tissue levels are systematically reviewed, taking lymphomas as an example. First, detecting the physics of cancers at multiple scales is summarized, along with antibody-based therapy for lymphomas. Next, the principles and methods of AFM imaging and measurements are summarized. After that, utilizing AFM to probe the physics of tumors is reviewed from several facets, including topographical imaging, mechanical measurement, molecular recognition, primary cell detection, and tissue characterization. In particular, the motivations and state-of-the-art overview of each facet is presented. Finally the current limitations and future directions of AFM assays for cancer investigations are discussed..
Language英语
WOS SubjectEngineering, Electrical & Electronic ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS KeywordRITUXIMAB-INDUCED CHANGES ; SINGLE-MOLECULE ; CANCER-CELLS ; B-CELL ; MEMBRANE-PROTEINS ; BREAST-CANCER ; EXTRACELLULAR-MATRIX ; MECHANICAL-PROPERTIES ; ELASTIC PROPERTIES ; LIVING CELLS
WOS Research AreaEngineering ; Science & Technology - Other Topics ; Materials Science ; Physics
Funding ProjectNational Natural Science Foundation of China[61873258] ; National Natural Science Foundation of China[61503372] ; National Natural Science Foundation of China[U1613220] ; National Natural Science Foundation of China[61433017] ; Youth Innovation Promotion Association[CAS 2017243] ; CAS FEA International Partnership Program for Creative Research Teams
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Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/23676
Collection机器人学研究室
Corresponding AuthorLi M(李密); Liu LQ(刘连庆)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Shenyang, Liaoning Province China 110016
2.Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang 110016, China
3.Department of Industrial and Manufacturing Systems Engineering, The University of Hong Kong, Hong Kong, China
Recommended Citation
GB/T 7714
Li M,Xi N,Wang YC,et al. Atomic force microscopy in probing tumor physics for nanomedicine[J]. IEEE Transactions on Nanotechnology,2019,18:83-113.
APA Li M,Xi N,Wang YC,&Liu LQ.(2019).Atomic force microscopy in probing tumor physics for nanomedicine.IEEE Transactions on Nanotechnology,18,83-113.
MLA Li M,et al."Atomic force microscopy in probing tumor physics for nanomedicine".IEEE Transactions on Nanotechnology 18(2019):83-113.
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