| Atomic force microscopy in probing tumor physics for nanomedicine | |
Li M(李密)1,2 ; Xi N(席宁)3; Wang YC(王越超)1,2; Liu LQ(刘连庆)1,2
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| Department | 机器人学研究室 |
| Source Publication | IEEE Transactions on Nanotechnology
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| ISSN | 1536-125X |
| 2019 | |
| Volume | 18Pages:83-113 |
| Indexed By | SCI ; EI |
| EI Accession number | 20184906208046 |
| WOS ID | WOS:000455709300011 |
| Contribution Rank | 1 |
| Funding Organization | National Natural Science Foundation of China ; Youth Innovation Promotion Association ; CAS FEA International Partnership Program for Creative Research Teams |
| Keyword | atomic force microscopy physical oncology nanomedicine cell mechanics molecular recognition tissue characterization |
| Abstract | Investigating the physics in tumor development and progression has been recognized as a promising way to advance both basic cancer research and clinical cancer treatment. The advent of atomic force microscopy (AFM) provides an exciting multifunctional tool for investigating the physical properties of biological systems under aqueous conditions with unprecedented spatiotemporal resolution, opening new possibilities for nanomedicine in physical oncology. In this article, the biomedical applications of AFM to investigate the physical sciences in oncology at single-cell, single-molecule, and tissue levels are systematically reviewed, taking lymphomas as an example. First, detecting the physics of cancers at multiple scales is summarized, along with antibody-based therapy for lymphomas. Next, the principles and methods of AFM imaging and measurements are summarized. After that, utilizing AFM to probe the physics of tumors is reviewed from several facets, including topographical imaging, mechanical measurement, molecular recognition, primary cell detection, and tissue characterization. In particular, the motivations and state-of-the-art overview of each facet is presented. Finally the current limitations and future directions of AFM assays for cancer investigations are discussed.. |
| Language | 英语 |
| WOS Subject | Engineering, Electrical & Electronic ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| WOS Keyword | RITUXIMAB-INDUCED CHANGES ; SINGLE-MOLECULE ; CANCER-CELLS ; B-CELL ; MEMBRANE-PROTEINS ; BREAST-CANCER ; EXTRACELLULAR-MATRIX ; MECHANICAL-PROPERTIES ; ELASTIC PROPERTIES ; LIVING CELLS |
| WOS Research Area | Engineering ; Science & Technology - Other Topics ; Materials Science ; Physics |
| Funding Project | CAS FEA International Partnership Program for Creative Research Teams ; Youth Innovation Promotion Association[CAS 2017243] ; National Natural Science Foundation of China[61433017] ; National Natural Science Foundation of China[U1613220] ; National Natural Science Foundation of China[61503372] ; National Natural Science Foundation of China[61873258] ; National Natural Science Foundation of China[61873258] ; National Natural Science Foundation of China[61503372] ; National Natural Science Foundation of China[U1613220] ; National Natural Science Foundation of China[61433017] ; Youth Innovation Promotion Association[CAS 2017243] ; CAS FEA International Partnership Program for Creative Research Teams |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sia.cn/handle/173321/23676 |
| Collection | 机器人学研究室 |
| Corresponding Author | Li M(李密); Liu LQ(刘连庆) |
| Affiliation | 1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Shenyang, Liaoning Province China 110016 2.Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang 110016, China 3.Department of Industrial and Manufacturing Systems Engineering, The University of Hong Kong, Hong Kong, China |
| Recommended Citation GB/T 7714 | Li M,Xi N,Wang YC,et al. Atomic force microscopy in probing tumor physics for nanomedicine[J]. IEEE Transactions on Nanotechnology,2019,18:83-113. |
| APA | Li M,Xi N,Wang YC,&Liu LQ.(2019).Atomic force microscopy in probing tumor physics for nanomedicine.IEEE Transactions on Nanotechnology,18,83-113. |
| MLA | Li M,et al."Atomic force microscopy in probing tumor physics for nanomedicine".IEEE Transactions on Nanotechnology 18(2019):83-113. |
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| Atomic Force Microsc（12834KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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