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Mechanisms involved in inflammatory pulmonary fibrosis induced by lunar dust simulant in rats
Sun Y(孙燕)1,2,3; Liu JG(刘金国)3; Zhang, Xiaoping2,4; Li, Xiongyao5; Zhou, Baichu1; Lv, Zengjing1
Department空间自动化技术研究室
Source PublicationEnvironmental Toxicology
ISSN1520-4081
2019
Volume34Issue:2Pages:131-140
Indexed BySCI ; EI
EI Accession number20184906209012
WOS IDWOS:000455775800004
Contribution Rank1
Funding OrganizationDoctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; National Natural Science Foundation of China ; Open Projects Funding of Lunar and Planetary Science Laboratory, MUST Partner Laboratory of Key Laboratory of Lunar and Deep Space Exploration, CAS ; Science and Technology Development Fund (FDCT) of Macau ; Science and Technology Research Fund of Shenyang Medical College
Keywordfibrosis inflammation lunar dust lung oxidative stress
AbstractLunar dust is one of the biggest risk factors in the future manned exploration mission. Much is not known about the pulmonary toxicity of lunar dust. The aim of this study was to evaluate the lung inflammation and oxidative stress induced by subacute exposure to lunar dust stimulant (LDS) in rats. Wistar rats were intratracheally administered LDS, twice a week for 3 weeks. Inflammatory cell counting and cytokine assays using bronchoalveolar lavage fluid (BALF) were performed. Lung tissues were processed for histopathological examination and immunohistochemical staining. Biomarkers of oxidative stress and genes and proteins related to inflammation and fibrosis in lung tissue were also determined. The neutrophil count in the BALF of LDS-exposed groups was higher than that in controls.
Language英语
WOS SubjectEnvironmental Sciences ; Toxicology ; Water Resources
WOS KeywordNF-KAPPA-B ; PARTICULATE MATTER ; TNF-ALPHA ; MARTIAN DUSTS ; TOXICITY ; MICE ; PARTICLES ; EXPOSURE ; EXPRESSION ; RESPONSES
WOS Research AreaEnvironmental Sciences & Ecology ; Toxicology ; Water Resources
Funding ProjectDoctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department[20170520437] ; National Natural Science Foundation of China[51775541] ; Open Projects Funding of Lunar and Planetary Science Laboratory, MUST Partner Laboratory of Key Laboratory of Lunar and Deep Space Exploration, CAS[119/2017/A3] ; Science and Technology Development Fund (FDCT) of Macau[020/2014/A1] ; Science and Technology Research Fund of Shenyang Medical College[20171020]
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Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/23681
Collection空间自动化技术研究室
Corresponding AuthorSun Y(孙燕); Liu JG(刘金国)
Affiliation1.College of Basic Medical Sciences, Shenyang Medical College, Shenyang, China
2.Lunar and Planetary Science Laboratory, MUST-Partner Laboratory of Key Laboratory of Lunar and Deep Space Exploration, CAS, China
3.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
4.Lunar and Planetary Science Laboratory, Macau University of Science and Technology, China
5.Center for Lunar and Planetary Sciences, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, China
Recommended Citation
GB/T 7714
Sun Y,Liu JG,Zhang, Xiaoping,et al. Mechanisms involved in inflammatory pulmonary fibrosis induced by lunar dust simulant in rats[J]. Environmental Toxicology,2019,34(2):131-140.
APA Sun Y,Liu JG,Zhang, Xiaoping,Li, Xiongyao,Zhou, Baichu,&Lv, Zengjing.(2019).Mechanisms involved in inflammatory pulmonary fibrosis induced by lunar dust simulant in rats.Environmental Toxicology,34(2),131-140.
MLA Sun Y,et al."Mechanisms involved in inflammatory pulmonary fibrosis induced by lunar dust simulant in rats".Environmental Toxicology 34.2(2019):131-140.
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