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Advances in atomic force microscopy for single-cell analysis
Li M(李密)1,2; Xi N(席宁)3; Wang YC(王越超)1,2; Liu LQ(刘连庆)1,2
Department机器人学研究室
Source PublicationNano Research
ISSN1998-0124
2019
Volume12Issue:4Pages:703-718
Indexed BySCI ; EI ; CSCD
EI Accession number20185106265543
WOS IDWOS:000463003600001
CSCD IDCSCD:6455349
Contribution Rank1
Keywordatomic force microscopy single-cell analysis cellular morphology cellular mechanics cellular manipulation
AbstractSingle-cell analysis has been considered as a promising way to uncover the underlying mechanisms guiding the mysteries of life activities, which considerably complements traditional ensemble assays and yields novel insights into cell biology. The advent of atomic force microscopy (AFM) provides a potent tool for investigating the structures and properties of native biological samples at the micro/nanoscale under near-physiological conditions, which promotes the studies of single-cell behaviors. In the past decades, AFM has achieved great success in single-cell observation and manipulation for biomedical applications, demonstrating the excellent capabilities of AFM in addressing biological issues at the single-cell level with unprecedented spatiotemporal resolution. In this article, we review the recent advances in single-cell analysis that has been made with the utilization of AFM, and provide perspectives for future progression. [Figure not available: see fulltext.].
Language英语
WOS SubjectChemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS KeywordCANCER-CELLS ; LIVING CELLS ; MICROMECHANICAL PROPERTIES ; NANOMECHANICAL SIGNATURE ; DECELLULARIZED MATRICES ; MECHANICAL-PROPERTIES ; EXTRACELLULAR-MATRIX ; MEMBRANE-PROTEINS ; AFM-CANTILEVERS ; THIN SAMPLES
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
Funding ProjectNational Natural Science Foundation of China[61873258] ; CAS FEA International Partnership Program for Creative Research Teams ; Youth Innovation Promotion Association CAS[2017243] ; National Natural Science Foundation of China[U1613220] ; National Natural Science Foundation of China[61503372] ; National Natural Science Foundation of China[61433017] ; National Natural Science Foundation of China[61433017] ; National Natural Science Foundation of China[61503372] ; National Natural Science Foundation of China[U1613220] ; Youth Innovation Promotion Association CAS[2017243] ; CAS FEA International Partnership Program for Creative Research Teams ; National Natural Science Foundation of China[61873258]
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/23936
Collection机器人学研究室
Corresponding AuthorLi M(李密); Liu LQ(刘连庆)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang 110016, China
3.Department of Industrial and Manufacturing Systems Engineering, The University of Hong Kong, 999077, Hong Kong
Recommended Citation
GB/T 7714
Li M,Xi N,Wang YC,et al. Advances in atomic force microscopy for single-cell analysis[J]. Nano Research,2019,12(4):703-718.
APA Li M,Xi N,Wang YC,&Liu LQ.(2019).Advances in atomic force microscopy for single-cell analysis.Nano Research,12(4),703-718.
MLA Li M,et al."Advances in atomic force microscopy for single-cell analysis".Nano Research 12.4(2019):703-718.
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