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Nanoscale Multiparametric Imaging of Peptide-Assembled Nanofibrillar Hydrogels by Atomic Force Microscopy
Li M(李密)1,2; Xi N(席宁)3; Wang YC(王越超)1,2; Liu LQ(刘连庆)1,2
Department机器人学研究室
Source PublicationIEEE TRANSACTIONS ON NANOTECHNOLOGY
ISSN1536-125X
2019
Volume18Pages:315-328
Indexed BySCI ; EI
EI Accession number20191406737501
WOS IDWOS:000463063500003
Contribution Rank1
Funding OrganizationNational Natural Science Foundation of China
KeywordAtomic force microscopy peak force tapping multiparametric imaging peptide self-assembly nanofibrillar hydrogels
AbstractPeptide-assembled hydrogels have emerged as a promising biomaterial for tissue engineering due to their controllable structures as well as biocompatible and biodegradable characteristics. However, the detailed situations of nanofibrillar mechanics during the formation of peptide-assembled hydrogels remain poorly understood. The advent of atomic force microscopy (AFM) provides a powerful tool for nanoscale characterizations and measurements of native biomaterials without pretreatments. In this paper, AFM peak force tapping multiparametric imaging was utilized to investigate the morphology and mechanics of individual nanofibrils during the gelation and degradation process of peptide-assembly hydrogels. Nanofibrillar hydrogels were fabricated by the self-assembly reactions of phenylalanine peptide molecules. AFM topography imaging distinctly visualized the diverse assembly behaviors of peptide-formed nanofibrils during the gelation and degradation of hydrogels, which were significantly correlated with the changes of nanofibrillar mechanics (Young's modulus, adhesion force, deformation, and persistence length) revealed by AFM mechanical imaging. The research provides a novel idea for nanoscale imaging and mechanical analysis of nanofibrillar behaviors in peptide-assembled hydrogels, which will have potential impacts on the characterization and design of supramolecular biomaterials.
Language英语
WOS SubjectEngineering, Electrical & Electronic ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS KeywordCANCER-CELLS ; NANOMECHANICAL PROPERTIES ; BETA-SHEET ; MECHANICS ; DNA ; ADHESION ; MATRIX ; FLEXIBILITY ; AFM ; NANOPARTICLES
WOS Research AreaEngineering ; Science & Technology - Other Topics ; Materials Science ; Physics
Funding ProjectNational Natural Science Foundation of China[61873258] ; National Natural Science Foundation of China[61503372] ; National Natural Science Foundation of China[U1613220] ; National Natural Science Foundation of China[61873258] ; National Natural Science Foundation of China[61503372] ; National Natural Science Foundation of China[U1613220]
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Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/24589
Collection机器人学研究室
Corresponding AuthorLi M(李密); Liu LQ(刘连庆)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang 110016, China
3.Department of Industrial and Manufacturing Systems Engineering, The University of Hong Kong, Hong Kong
Recommended Citation
GB/T 7714
Li M,Xi N,Wang YC,et al. Nanoscale Multiparametric Imaging of Peptide-Assembled Nanofibrillar Hydrogels by Atomic Force Microscopy[J]. IEEE TRANSACTIONS ON NANOTECHNOLOGY,2019,18:315-328.
APA Li M,Xi N,Wang YC,&Liu LQ.(2019).Nanoscale Multiparametric Imaging of Peptide-Assembled Nanofibrillar Hydrogels by Atomic Force Microscopy.IEEE TRANSACTIONS ON NANOTECHNOLOGY,18,315-328.
MLA Li M,et al."Nanoscale Multiparametric Imaging of Peptide-Assembled Nanofibrillar Hydrogels by Atomic Force Microscopy".IEEE TRANSACTIONS ON NANOTECHNOLOGY 18(2019):315-328.
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