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Development of an image biosensor based on an optogenetically engineered cell for visual prostheses
Li GX(李恭新)1,2,3; Wang FF(王飞飞)4; Yang WG(杨文广)5; Yang J(杨佳)1,2,6; Wang YC(王越超)1,2; Wang WX(王文学)1,2; Liu LQ(刘连庆)1,2
Department机器人学研究室
Source PublicationNanoscale
ISSN2040-3364
2019
Volume11Issue:28Pages:13213-13218
Indexed BySCI ; EI
EI Accession number20192907214389
WOS IDWOS:000476564300046
Contribution Rank1
Funding OrganizationNational Key R & D Program of China ; Natural Science Foundation of Jiangsu Province of China ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences, CAS
AbstractVisual prostheses provide blind patients with artificial vision via electrical stimulation of surviving visual cells resulting in partial restoration of vision in many patients. However, high-resolution visual perception, long-term biocompatibility and safety remain the significant challenges of existing visual prostheses. Here, we present a novel method to develop a new visual prosthesis using living cells as integrated electronics and implantable microelectrodes. The living cells modified with channelrhodopsin-2 showed excellent light-sensitive properties and encoded image information with cellular deformations triggered by light stimulation. The photoresponsive properties of the cells were determined using a single pixel imaging system, which indicated that the cells can act as a good light-sensitive biosensor. Additionally, the imaging feasibility of the cells was further validated through successful and clear imaging of several object scenes using the same system. This work represents a step toward the design and use of living cells as an image biosensor for the development of a new generation of high-resolution visual prostheses.
Language英语
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS KeywordRETINAL PROSTHESES ; IMPLANTATION ; TRIAL
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
Funding ProjectKey Research Program of Frontier Sciences, CAS[QYZDB-SSW-JSC008] ; National Natural Science Foundation of China[61727811] ; National Natural Science Foundation of China[61573341] ; National Natural Science Foundation of China[91848201] ; National Natural Science Foundation of China[U1813210] ; National Natural Science Foundation of China[U1613220] ; National Natural Science Foundation of China[91748212] ; Natural Science Foundation of Jiangsu Province of China[BK20180592] ; National Key R & D Program of China[2018YFB1304700] ; National Key R & D Program of China[2018YFB1304700] ; Natural Science Foundation of Jiangsu Province of China[BK20180592] ; National Natural Science Foundation of China[91748212] ; National Natural Science Foundation of China[U1613220] ; National Natural Science Foundation of China[U1813210] ; National Natural Science Foundation of China[91848201] ; National Natural Science Foundation of China[61573341] ; National Natural Science Foundation of China[61727811] ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-JSC008]
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Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/25317
Collection机器人学研究室
Corresponding AuthorWang WX(王文学); Liu LQ(刘连庆)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang 110016, China
3.Key Laboratory of Advanced Process Control for Light Industry (Ministry of Education), Institute of Automation, Jiangnan University, Wuxi 214122, China
4.Department of Chemistry, Stanford University, Stanford, CA 94305, United States
5.School of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, China
6.University of Chinese Academy of Sciences, Beijing 100049, China
Recommended Citation
GB/T 7714
Li GX,Wang FF,Yang WG,et al. Development of an image biosensor based on an optogenetically engineered cell for visual prostheses[J]. Nanoscale,2019,11(28):13213-13218.
APA Li GX.,Wang FF.,Yang WG.,Yang J.,Wang YC.,...&Liu LQ.(2019).Development of an image biosensor based on an optogenetically engineered cell for visual prostheses.Nanoscale,11(28),13213-13218.
MLA Li GX,et al."Development of an image biosensor based on an optogenetically engineered cell for visual prostheses".Nanoscale 11.28(2019):13213-13218.
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