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基于多喷头生物3D打印系统的管腔型结构构建
Alternative TitleFabrication of Lumen Structure Based on Multi-Nozzle Biological 3D Printing System
王强1,2; 郑雄飞2; 王赫然2; 慕丽1
Department机器人学研究室
Source Publication机械设计与制造
ISSN1001-3997
2019
Issue11Pages:265-268
Contribution Rank1
Funding Organization国家自然科学基金(51305438) ; 国家高技术研究发展计划(863计划,2015AA020312)
Keyword生物3D打印 多喷头 管腔结构 溶芯材料
Abstract

基于多喷头生物3D打印系统和溶芯支撑法,运用超低温打印技术,以胶原为管壁材料,水凝胶F127为溶芯材料构建复合管腔结构,经过京尼平溶液交联及冻干处理后将支架浸泡在1℃的去离子水中以去除溶芯材料,从而获得胶原管腔支架结构;同时探究了以明胶/海藻酸钠为管壁结构,明胶材料为溶芯的管结构制备技术,实验证明明胶作为溶芯材料制备管结构的可行性。制备出了具有较好结构及力学性能的胶原和明胶/海藻酸钠管腔支架结构。该多喷头生物3D打印系统以溶芯工艺的方法,在构建管腔型生物结构方面具有很好的效果,为临床及再生医学提供了重要的制造工艺基础。

Other Abstract

This study is based on the multi-nozzle biological 3D printing system and the solvus. The composite tube structure is constructed by using the ultra-low temperature printing technique,the collagen as the wall material and the hydrogel F127 as the core material. After the solution is crosslinked and freeze-dried,the stent is immersed in deionized water at 1℃ to remove the core material. The structure of the collagen lumen is obtained. The technique of gelatin/sodium alginate as the wall structure and gelatin is used as the core. The feasibility of the gelatin regards as a core material for the preparation of tube structure. The structures of collagen and gelatin/alginate lumen stent with good structural and mechanical properties are prepared. The multi-nozzle biological 3D printing system has a good effect in the construction of luminal bio-structure by the method of soldering process,which provides an important manufacturing process base for clinical and regenerative medicine.

Language中文
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/25862
Collection机器人学研究室
Corresponding Author王强
Affiliation1.沈阳理工大学机械工程学院
2.中国科学院沈阳自动化研究所机器人学国家重点实验室
Recommended Citation
GB/T 7714
王强,郑雄飞,王赫然,等. 基于多喷头生物3D打印系统的管腔型结构构建[J]. 机械设计与制造,2019(11):265-268.
APA 王强,郑雄飞,王赫然,&慕丽.(2019).基于多喷头生物3D打印系统的管腔型结构构建.机械设计与制造(11),265-268.
MLA 王强,et al."基于多喷头生物3D打印系统的管腔型结构构建".机械设计与制造 .11(2019):265-268.
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