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Facile method for fabricating microfluidic chip integrated with microwell arrays for cell trapping
Wu, Hongyue1,2; Ge ZX(葛治星)2,3; Yang WG(杨文广)4; Wang XD(王晓朵)2; Wang Xiaodong1; Yu HB(于海波)2
Department机器人学研究室
Source PublicationMicromachines
ISSN2072666X
2019
Volume10Issue:11Pages:1-10
Indexed BySCI ; EI
EI Accession number20194807757717
WOS IDWOS:000502255300005
Contribution Rank1
Funding OrganizationNational Key R&D Program of China (Project No. 2018YFB1304900) ; National Natural Science Foundation of China (Project No. 61727811, 61803366, 61803323, and 91748212) ; CAS FEA International Partnership Program for Creative Research Teams ; Youth Innovation Promotion Association CAS
Keywordmicrostructure fabrication microwell arrays cell capture microfluidic chip
Abstract

With the development of biomedical technology, personalized diagnosis and treatment at the single-cell level are becoming more important in the medical field. As one of the most powerful tools, microfluidic chips have shown significant potential for various applications related to cell separation, cell proliferation, and cell behavior analysis. However, fabricating microfluidic devices requires complicated procedures and high-cost equipment. In this study, an optofluidic maskless lithography method was proposed for rapid fabrication of microfluidic devices integrated with microwells. Through the use of this approach, microwells can be on-line designed and the exposure patterns can be modulated. Single or multi polystyrene microspheres were successfully trapped by using the designed microwells. The capture of MCF-7 cells and cell arrays indicated that the microfluidic devices fabricated in the present study can be applied for cell research. © 2019 by the authors.

Language英语
WOS SubjectNanoscience & Nanotechnology ; Instruments & Instrumentation
WOS KeywordSINGLE ; CAPTURE ; DEVICE
WOS Research AreaScience & Technology - Other Topics ; Instruments & Instrumentation
Funding ProjectNational Key R&D Program of China[2018YFB1304900] ; National Natural Science Foundation of China[61727811] ; National Natural Science Foundation of China[61803366] ; National Natural Science Foundation of China[61803323] ; National Natural Science Foundation of China[91748212] ; CAS FEA International Partnership Program for Creative Research Teams ; Youth Innovation Promotion Association CAS
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Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/25928
Collection机器人学研究室
Corresponding AuthorYu HB(于海波)
Affiliation1.School of Mechanical Engineering and Automation, Northeastern University, Shenyang 110004, China
2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
3.University of the Chinese Academy of Sciences, Beijing 100049, China
4.School of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, China
Recommended Citation
GB/T 7714
Wu, Hongyue,Ge ZX,Yang WG,et al. Facile method for fabricating microfluidic chip integrated with microwell arrays for cell trapping[J]. Micromachines,2019,10(11):1-10.
APA Wu, Hongyue,Ge ZX,Yang WG,Wang XD,Wang Xiaodong,&Yu HB.(2019).Facile method for fabricating microfluidic chip integrated with microwell arrays for cell trapping.Micromachines,10(11),1-10.
MLA Wu, Hongyue,et al."Facile method for fabricating microfluidic chip integrated with microwell arrays for cell trapping".Micromachines 10.11(2019):1-10.
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