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Microfluidic-based cancer cell separation using active and passive mechanisms
Liang WF(梁文峰)1; Liu, Jing1; Yang XL(杨谢柳)1; Zhang, Qi1; Yang WG(杨文广)2; Zhang, Hemin3; Liu LQ(刘连庆)4
Department机器人学研究室
Source PublicationMICROFLUIDICS AND NANOFLUIDICS
ISSN1613-4982
2020
Volume24Issue:4Pages:1-19
Indexed BySCI ; EI
EI Accession number20201408370444
WOS IDWOS:000521150500001
Contribution Rank4
Funding OrganizationNational Natural Science Foundation of ChinaNational Natural Science Foundation of China [61973224, 61925307, U1613220, 61803323] ; Natural Science Foundation of Liaoning ProvinceNatural Science Foundation of Liaoning Province [2019-KF-01-15, 2019-ZD-0673] ; Scientific Research Innovation Cultivation Project of Shenyang Jianzhu University [CXPY2017012]
KeywordCell separation Dielectrophoresis Magnetic Acoustic Microfluidics Passive microfluidics
Abstract

The demand for on-chip cancer cell separation in biomedical, bio-sensor, bio-detection, personalized medicine, and clinical diagnostic fields has resulted in a variety of studies focusing on this theme. Accurate, high-throughput, and non-invasive separation of individual cells is also an essential enabling technique to move cellular biology, biomedicine, and biotechnology forward. Due to its great potential to solve bio-related problems, this cutting-edge technique has become a topic of concern for many studies on micro-manipulation methods. Hence, we present here a comprehensive review on recent developments of cancer cell separation utilizing various microfluidic-based methods, including dielectrophoresis-, magnetic-, acoustic-, and passive microfluidic-based ones. The review includes an overview of how these methods work along with a description of the experimental results using each method as well as their respective advantages and disadvantages. The paper is wrapped up with a discussion of the current challenges and future prospects in the cell separation technique. Our conclusion is that this technique will allow more opportunities for biomedical and bioengineering researchers to improve lab-on-a-chip technologies, and will have far-reaching implications for bio-related studies and applications.

Language英语
WOS SubjectNanoscience & Nanotechnology ; Instruments & Instrumentation ; Physics, Fluids & Plasmas
WOS KeywordCIRCULATING TUMOR-CELLS ; OPTICALLY-INDUCED-DIELECTROPHORESIS ; LABEL-FREE ISOLATION ; DEFORMABILITY-BASED SEPARATION ; RESISTANT PROSTATE-CANCER ; IRON-OXIDE NANOPARTICLES ; MAGNETIC SEPARATION ; LUNG-CANCER ; PARTICLE SEPARATION ; PERIPHERAL-BLOOD
WOS Research AreaScience & Technology - Other Topics ; Instruments & Instrumentation ; Physics
Funding ProjectNational Natural Science Foundation of China[61973224] ; National Natural Science Foundation of China[61925307] ; National Natural Science Foundation of China[U1613220] ; National Natural Science Foundation of China[61803323] ; Natural Science Foundation of Liaoning Province[2019-KF-01-15] ; Natural Science Foundation of Liaoning Province[2019-ZD-0673] ; Scientific Research Innovation Cultivation Project of Shenyang Jianzhu University[CXPY2017012]
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/26645
Collection机器人学研究室
Corresponding AuthorLiang WF(梁文峰); Zhang, Hemin; Liu LQ(刘连庆)
Affiliation1.School of Mechanical Engineering, Shenyang Jianzhu University, Shenyang 110168, China
2.School of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, China
3.Department of Neurology, The People’s Hospital of Liaoning Province, Shenyang 110016, China
4.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
Recommended Citation
GB/T 7714
Liang WF,Liu, Jing,Yang XL,et al. Microfluidic-based cancer cell separation using active and passive mechanisms[J]. MICROFLUIDICS AND NANOFLUIDICS,2020,24(4):1-19.
APA Liang WF.,Liu, Jing.,Yang XL.,Zhang, Qi.,Yang WG.,...&Liu LQ.(2020).Microfluidic-based cancer cell separation using active and passive mechanisms.MICROFLUIDICS AND NANOFLUIDICS,24(4),1-19.
MLA Liang WF,et al."Microfluidic-based cancer cell separation using active and passive mechanisms".MICROFLUIDICS AND NANOFLUIDICS 24.4(2020):1-19.
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