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Determination of dielectric properties of cells using ac electrokinetic-based microfluidic platform: A review of recent advances
Liang WF(梁文峰)1; Yang XL(杨谢柳)1; Wang, Junhai1; Wang YC(王越超)2; Yang WG(杨文广)3; Liu LQ(刘连庆)2
Department机器人学研究室
Source PublicationMicromachines
ISSN2072-666X
2020
Volume11Issue:5Pages:1-24
Indexed BySCI ; EI
EI Accession number20202308800880
WOS IDWOS:000540761400063
Contribution Rank2
Funding OrganizationNational Natural Science Foundation of China (Project Nos.: 61973224, 61925307, 51805336, U1613220, U1908215 and 61803323) ; Natural Science Foundation of Liaoning Province (Project Nos.: 2019-KF-01-15 and 2019-ZD-0673)
Keywordelectro-rotation dielectrophoresis optically-induced dielectrophoreis alternating current (AC) electrokinetic cell dielectric properties microfluidic
Abstract

Cell dielectric properties, a type of intrinsic property of cells, can be used as electrophysiological biomarkers that offer a label-free way to characterize cell phenotypes and states, purify clinical samples, and identify target cancer cells. Here, we present a review of the determination of cell dielectric properties using alternating current (AC) electrokinetic-based microfluidic mechanisms, including electro-rotation (ROT) and dielectrophoresis (DEP). The review covers theoretically how ROT and DEP work to extract cell dielectric properties. We also dive into the details of differently structured ROT chips, followed by a discussion on the determination of cell dielectric properties and the use of these properties in bio-related applications. Additionally, the review offers a look at the future challenges facing the AC electrokinetic-based microfluidic platform in terms of acquiring cell dielectric parameters. Our conclusion is that this platform will bring biomedical and bioengineering sciences to the next level and ultimately achieve the shift from lab-oriented research to real-world applications.

Language英语
WOS SubjectNanoscience & Nanotechnology ; Instruments & Instrumentation
WOS KeywordATOMIC-FORCE MICROSCOPY ; OPTICALLY-INDUCED-DIELECTROPHORESIS ; CANCER-CELLS ; SINGLE-CELL ; MEMBRANE CAPACITANCE ; AUTOMATED ELECTROROTATION ; REFRACTIVE-INDEX ; DRUG-RESISTANCE ; LIVING CELLS ; HL-60 CELLS
WOS Research AreaScience & Technology - Other Topics ; Instruments & Instrumentation
Funding ProjectNational Natural Science Foundation of China[61973224] ; National Natural Science Foundation of China[61925307] ; National Natural Science Foundation of China[51805336] ; National Natural Science Foundation of China[U1613220] ; National Natural Science Foundation of China[U1908215] ; National Natural Science Foundation of China[61803323] ; Natural Science Foundation of Liaoning Province[2019-KF-01-15] ; Natural Science Foundation of Liaoning Province[2019-ZD-0673]
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/27097
Collection机器人学研究室
Corresponding AuthorLiang WF(梁文峰); Liu LQ(刘连庆)
Affiliation1.School of Mechanical Engineering, Shenyang Jianzhu University, Shenyang 110168, China
2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
3.School of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, China
Recommended Citation
GB/T 7714
Liang WF,Yang XL,Wang, Junhai,et al. Determination of dielectric properties of cells using ac electrokinetic-based microfluidic platform: A review of recent advances[J]. Micromachines,2020,11(5):1-24.
APA Liang WF,Yang XL,Wang, Junhai,Wang YC,Yang WG,&Liu LQ.(2020).Determination of dielectric properties of cells using ac electrokinetic-based microfluidic platform: A review of recent advances.Micromachines,11(5),1-24.
MLA Liang WF,et al."Determination of dielectric properties of cells using ac electrokinetic-based microfluidic platform: A review of recent advances".Micromachines 11.5(2020):1-24.
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