| Dynamically directing cell organization via micro-hump structure patterned cell-adhered interfaces | |
Yang WG(杨文广)1; Sun LJ(孙路静)1; Cai SX(蔡树向)1; Chen, Yibao1; Liang WF(梁文峰)2; Zhou PL(周培林)3,4 ; Yu HB(于海波)3,4; Wang YC(王越超)3,4; Liu LQ(刘连庆)3,4
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| Department | 机器人学研究室 |
| Source Publication | LAB ON A CHIP
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| ISSN | 1473-0197 |
| 2020 | |
| Volume | 20Issue:14Pages:2447-2452 |
| Indexed By | SCI ; EI |
| EI Accession number | 20203008979841 |
| WOS ID | WOS:000548638600015 |
| Contribution Rank | 3 |
| Funding Organization | National Natural Science Foundation of ChinaNational Natural Science Foundation of China [61973224, 61803323] ; Natural Science Foundation of Shandong ProvinceNatural Science Foundation of Shandong Province [ZR2019BF049] |
| Abstract | Cell adhesion plays an important role in cell communication, organ formation and tissue maintenance. Spatial microstructure patterning has the capability to regulate cell functions such as cell adhesion and cell proliferation as well as cellular mechanical properties. In this study, we present a simple method to fabricate micro-hump patterned interfaces based on electrohydrodynamic jet (E-jet) printing to control and direct cell organization. Micro-hump structures were rapidly fabricated by E-jet printing and arbitrary cell patterns can be achieved by selective cell adhesion induced by this surface topography. Furthermore, cellular mechanical properties were regulated by changing the density of microstructures. The technique we proposed could dynamically direct cell organization in a controlled manner, providing help for exploring the fundamental mechanism of cell adhesion and sensing. |
| Language | 英语 |
| WOS Subject | Biochemical Research Methods ; Chemistry, Multidisciplinary ; Chemistry, Analytical ; Nanoscience & Nanotechnology ; Instruments & Instrumentation |
| WOS Keyword | STEM-CELL ; SUBSTRATE MICROTOPOGRAPHY ; MECHANICAL-PROPERTIES ; ADHESION ; TOPOGRAPHY ; SURFACE ; DIFFERENTIATION ; PROLIFERATION ; MIGRATION ; RESPONSES |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation |
| Funding Project | National Natural Science Foundation of China[61973224] ; National Natural Science Foundation of China[61803323] ; Natural Science Foundation of Shandong Province[ZR2019BF049] |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sia.cn/handle/173321/27372 |
| Collection | 机器人学研究室 |
| Corresponding Author | Yang WG(杨文广); Yu HB(于海波); Liu LQ(刘连庆) |
| Affiliation | 1.School of Electromechanical and Automotive Engineering, Yantai University, China 2.School of Mechanical Engineering, Shenyang Jianzhu University, China 3.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, China 4.Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, China |
| Recommended Citation GB/T 7714 | Yang WG,Sun LJ,Cai SX,et al. Dynamically directing cell organization via micro-hump structure patterned cell-adhered interfaces[J]. LAB ON A CHIP,2020,20(14):2447-2452. |
| APA | Yang WG.,Sun LJ.,Cai SX.,Chen, Yibao.,Liang WF.,...&Liu LQ.(2020).Dynamically directing cell organization via micro-hump structure patterned cell-adhered interfaces.LAB ON A CHIP,20(14),2447-2452. |
| MLA | Yang WG,et al."Dynamically directing cell organization via micro-hump structure patterned cell-adhered interfaces".LAB ON A CHIP 20.14(2020):2447-2452. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Dynamically directin（4596KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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