Atomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues | |
Li M(李密)![]() ![]() ![]() | |
Department | 机器人学研究室 |
Source Publication | ACTA PHARMACOLOGICA SINICA
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ISSN | 1671-4083 |
2020 | |
Pages | 1-17 |
Indexed By | SCI |
WOS ID | WOS:000560282200001 |
Contribution Rank | 1 |
Funding Organization | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61922081, 61873258, U1613220, 91748212] ; Key Research Program of Frontier Sciences CAS [ZDBS-LY-JSC043] ; Youth Innovation Promotion Association CAS [2017243] ; LiaoNing Revitalization Talents Program [XLYC1907072] |
Keyword | atomic force microscopy tumor mechanics cancerous cell tumor microenvironment exosome extracellular matrix |
Abstract | Mechanics are intrinsic properties which appears throughout the formation, development, and aging processes of biological systems. Mechanics have been shown to play important roles in regulating the development and metastasis of tumors, and understanding tumor mechanics has emerged as a promising way to reveal the underlying mechanisms guiding tumor behaviors. In particular, tumors are highly complex diseases associated with multifaceted factors, including alterations in cancerous cells, tissues, and organs as well as microenvironmental cues, indicating that investigating tumor mechanics on multiple levels is significantly helpful for comprehensively understanding the effects of mechanics on tumor progression. Recently, diverse techniques have been developed for probing the mechanics of tumors, among which atomic force microscopy (AFM) has appeared as an excellent platform enabling simultaneously characterizing the structures and mechanical properties of living biological systems ranging from individual molecules and cells to tissue samples with unprecedented spatiotemporal resolution, offering novel possibilities for understanding tumor physics and contributing much to the studies of cancer. In this review, we survey the recent progress that has been achieved with the use of AFM for revealing micro/nanoscale mechanics in tumor development and metastasis. Challenges and future progress are also discussed. |
Language | 英语 |
WOS Subject | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
WOS Keyword | CANCER-MORTALITY PREDICTIONS ; EXTRACELLULAR-MATRIX ; MICROMECHANICAL PROPERTIES ; DECELLULARIZED MATRICES ; NANOMECHANICAL ANALYSIS ; ADHERENS JUNCTIONS ; ELASTIC PROPERTIES ; BASEMENT-MEMBRANE ; LIVING CELLS ; EXOSOMES |
WOS Research Area | Chemistry ; Pharmacology & Pharmacy |
Funding Project | National Natural Science Foundation of China[61922081] ; National Natural Science Foundation of China[61873258] ; National Natural Science Foundation of China[U1613220] ; National Natural Science Foundation of China[91748212] ; Key Research Program of Frontier Sciences CAS[ZDBS-LY-JSC043] ; Youth Innovation Promotion Association CAS[2017243] ; LiaoNing Revitalization Talents Program[XLYC1907072] |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.sia.cn/handle/173321/27544 |
Collection | 机器人学研究室 |
Corresponding Author | Li M(李密); Liu LQ(刘连庆) |
Affiliation | 1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China 2.Institutes for Robotics and IntelligentManufacturing, Chinese Academy of Sciences, Shenyang 110169, China 3.University of Chinese Academy of Sciences, Beijing 100049, China |
Recommended Citation GB/T 7714 | Li M,Wang YC,Liu LQ. Atomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues[J]. ACTA PHARMACOLOGICA SINICA,2020:1-17. |
APA | Li M,Wang YC,&Liu LQ.(2020).Atomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues.ACTA PHARMACOLOGICA SINICA,1-17. |
MLA | Li M,et al."Atomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues".ACTA PHARMACOLOGICA SINICA (2020):1-17. |
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Atomic force microsc(6229KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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