SIA OpenIR  > 机器人学研究室
Atomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues
Li M(李密); Wang YC(王越超); Liu LQ(刘连庆)
Department机器人学研究室
Source PublicationACTA PHARMACOLOGICA SINICA
ISSN1671-4083
2020
Pages1-17
Indexed BySCI
WOS IDWOS:000560282200001
Contribution Rank1
Funding OrganizationNational Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61922081, 61873258, U1613220, 91748212] ; Key Research Program of Frontier Sciences CAS [ZDBS-LY-JSC043] ; Youth Innovation Promotion Association CAS [2017243] ; LiaoNing Revitalization Talents Program [XLYC1907072]
Keywordatomic force microscopy tumor mechanics cancerous cell tumor microenvironment exosome extracellular matrix
Abstract

Mechanics are intrinsic properties which appears throughout the formation, development, and aging processes of biological systems. Mechanics have been shown to play important roles in regulating the development and metastasis of tumors, and understanding tumor mechanics has emerged as a promising way to reveal the underlying mechanisms guiding tumor behaviors. In particular, tumors are highly complex diseases associated with multifaceted factors, including alterations in cancerous cells, tissues, and organs as well as microenvironmental cues, indicating that investigating tumor mechanics on multiple levels is significantly helpful for comprehensively understanding the effects of mechanics on tumor progression. Recently, diverse techniques have been developed for probing the mechanics of tumors, among which atomic force microscopy (AFM) has appeared as an excellent platform enabling simultaneously characterizing the structures and mechanical properties of living biological systems ranging from individual molecules and cells to tissue samples with unprecedented spatiotemporal resolution, offering novel possibilities for understanding tumor physics and contributing much to the studies of cancer. In this review, we survey the recent progress that has been achieved with the use of AFM for revealing micro/nanoscale mechanics in tumor development and metastasis. Challenges and future progress are also discussed.

Language英语
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS KeywordCANCER-MORTALITY PREDICTIONS ; EXTRACELLULAR-MATRIX ; MICROMECHANICAL PROPERTIES ; DECELLULARIZED MATRICES ; NANOMECHANICAL ANALYSIS ; ADHERENS JUNCTIONS ; ELASTIC PROPERTIES ; BASEMENT-MEMBRANE ; LIVING CELLS ; EXOSOMES
WOS Research AreaChemistry ; Pharmacology & Pharmacy
Funding ProjectNational Natural Science Foundation of China[61922081] ; National Natural Science Foundation of China[61873258] ; National Natural Science Foundation of China[U1613220] ; National Natural Science Foundation of China[91748212] ; Key Research Program of Frontier Sciences CAS[ZDBS-LY-JSC043] ; Youth Innovation Promotion Association CAS[2017243] ; LiaoNing Revitalization Talents Program[XLYC1907072]
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/27544
Collection机器人学研究室
Corresponding AuthorLi M(李密); Liu LQ(刘连庆)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.Institutes for Robotics and IntelligentManufacturing, Chinese Academy of Sciences, Shenyang 110169, China
3.University of Chinese Academy of Sciences, Beijing 100049, China
Recommended Citation
GB/T 7714
Li M,Wang YC,Liu LQ. Atomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues[J]. ACTA PHARMACOLOGICA SINICA,2020:1-17.
APA Li M,Wang YC,&Liu LQ.(2020).Atomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues.ACTA PHARMACOLOGICA SINICA,1-17.
MLA Li M,et al."Atomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues".ACTA PHARMACOLOGICA SINICA (2020):1-17.
Files in This Item:
File Name/Size DocType Version Access License
Atomic force microsc(6229KB)期刊论文出版稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li M(李密)]'s Articles
[Wang YC(王越超)]'s Articles
[Liu LQ(刘连庆)]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li M(李密)]'s Articles
[Wang YC(王越超)]'s Articles
[Liu LQ(刘连庆)]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li M(李密)]'s Articles
[Wang YC(王越超)]'s Articles
[Liu LQ(刘连庆)]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Atomic force microscopy for revealing micro nanoscale mechanics in tumor metastasis.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.