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Recent advances in AFM-based biological characterization and applications at multiple levels
Liang WF(梁文峰)1; Shi, Haohao1; Yang XL(杨谢柳)1; Wang, Junhai1; Yang WG(杨文广)2; Zhang, Hemin3; Liu LQ(刘连庆)4
Department机器人学研究室
Source PublicationSOFT MATTER
ISSN1744-683X
2020
Volume16Issue:39Pages:8962-8984
Indexed BySCI ; EI
EI Accession number20204309397799
WOS IDWOS:000577734200001
Contribution Rank4
Funding OrganizationNational Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61973224, 61925307, 51805336, U1613220, U1908215, 61803323] ; Natural Science Foundation of Liaoning ProvinceNatural Science Foundation of Liaoning Province [2019KF-01-15, 2019-ZD-0673]
KeywordATOMIC-FORCE MICROSCOPY MECHANICAL-PROPERTIES CANCER-CELLS TISSUE STIFFNESS MICROMECHANICAL PROPERTIES VISCOELASTIC PROPERTIES SINGLE-MOLECULE ADHESION VISUALIZATION MEMBRANE
Abstract

Atomic force microscopy (AFM) has found a wide range of bio-applications in the past few decades due to its ability to measure biological samples in natural environments at a high spatial resolution. AFM has become a key platform in biomedical, bioengineering and drug research fields, enabling mechanical and morphological characterization of live biological systems. Hence, we provide a comprehensive review on recent advances in the use of AFM for characterizing the biomechanical properties of multi-scale biological samples, ranging from molecule, cell to tissue levels. First, we present the fundamental principles of AFM and two AFM-based models for the characterization of biomechanical properties of biological samples, covering key AFM devices and AFM bioimaging as well as theoretical models for characterizing the elasticity and viscosity of biomaterials. Then, we elaborate on a series of new experimental findings through analysis of biomechanics. Finally, we discuss the future directions and challenges. It is envisioned that the AFM technique will enable many remarkable discoveries, and will have far-reaching impacts on bio-related studies and applications in the future.

Language英语
WOS SubjectChemistry, Physical ; Materials Science, Multidisciplinary ; Physics, Multidisciplinary ; Polymer Science
WOS KeywordATOMIC-FORCE MICROSCOPY ; MECHANICAL-PROPERTIES ; CANCER-CELLS ; TISSUE STIFFNESS ; MICROMECHANICAL PROPERTIES ; VISCOELASTIC PROPERTIES ; SINGLE-MOLECULE ; ADHESION ; VISUALIZATION ; MEMBRANE
WOS Research AreaChemistry ; Materials Science ; Physics ; Polymer Science
Funding ProjectNational Natural Science Foundation of China[61973224] ; National Natural Science Foundation of China[61925307] ; National Natural Science Foundation of China[51805336] ; National Natural Science Foundation of China[U1613220] ; National Natural Science Foundation of China[U1908215] ; National Natural Science Foundation of China[61803323] ; Natural Science Foundation of Liaoning Province[2019KF-01-15] ; Natural Science Foundation of Liaoning Province[2019-ZD-0673]
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/27762
Collection机器人学研究室
Corresponding AuthorLiang WF(梁文峰); Liu LQ(刘连庆)
Affiliation1.School of Mechanical Engineering, Shenyang Jianzhu University, Shenyang, 110168, China
2.School of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, China
3.Department of Neurology, The People’s Hospital of Liaoning Province, Shenyang 110016, China
4.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China.
Recommended Citation
GB/T 7714
Liang WF,Shi, Haohao,Yang XL,et al. Recent advances in AFM-based biological characterization and applications at multiple levels[J]. SOFT MATTER,2020,16(39):8962-8984.
APA Liang WF.,Shi, Haohao.,Yang XL.,Wang, Junhai.,Yang WG.,...&Liu LQ.(2020).Recent advances in AFM-based biological characterization and applications at multiple levels.SOFT MATTER,16(39),8962-8984.
MLA Liang WF,et al."Recent advances in AFM-based biological characterization and applications at multiple levels".SOFT MATTER 16.39(2020):8962-8984.
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