Recent Advances in Three-Dimensional Multicellular Spheroid Culture and Future Development | |
Shen, Honglin1; Cai SX(蔡树向)1; Wu, Chuanxiang1; Yang WG(杨文广)1; Yu HB(于海波)2![]() ![]() | |
Department | 机器人学研究室 |
Source Publication | MICROMACHINES
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ISSN | 2072-666X |
2021 | |
Volume | 12Issue:1Pages:1-21 |
Indexed By | SCI ; EI |
EI Accession number | 20210609901055 |
WOS ID | WOS:000610518200001 |
Contribution Rank | 2 |
Funding Organization | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61803323] ; Natural Science Foundation of Shandong ProvinceNatural Science Foundation of Shandong Province [ZR2019BF049] |
Keyword | cell spheroids three-dimensional cell culture tissue engineering |
Abstract | Three-dimensional multicellular spheroids (MCSs) have received extensive attention in the field of biomedicine due to their ability to simulate the structure and function of tissues in vivo more accurately than traditional in vitro two-dimensional models and to simulate cell-cell and cell extracellular matrix (ECM) interactions. It has become an important in vitro three-dimensional model for tumor research, high-throughput drug screening, tissue engineering, and basic biology research. In the review, we first summarize methods for MCSs generation and their respective advantages and disadvantages and highlight the advances of hydrogel and microfluidic systems in the generation of spheroids. Then, we look at the application of MCSs in cancer research and other aspects. Finally, we discuss the development direction and prospects of MCSs |
Language | 英语 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.sia.cn/handle/173321/28316 |
Collection | 机器人学研究室 |
Corresponding Author | Yang WG(杨文广) |
Affiliation | 1.School of Electromechanical and Automotive Engineering, Yantai University, Yantai 264005, China 2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China |
Recommended Citation GB/T 7714 | Shen, Honglin,Cai SX,Wu, Chuanxiang,et al. Recent Advances in Three-Dimensional Multicellular Spheroid Culture and Future Development[J]. MICROMACHINES,2021,12(1):1-21. |
APA | Shen, Honglin,Cai SX,Wu, Chuanxiang,Yang WG,Yu HB,&Liu LQ.(2021).Recent Advances in Three-Dimensional Multicellular Spheroid Culture and Future Development.MICROMACHINES,12(1),1-21. |
MLA | Shen, Honglin,et al."Recent Advances in Three-Dimensional Multicellular Spheroid Culture and Future Development".MICROMACHINES 12.1(2021):1-21. |
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Recent Advances in T(3920KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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