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An Intelligent Graphene-Based Biosensing Device for Cytokine Storm Syndrome Biomarkers Detection in Human Biofluids
Hao, Zhuang1,2,3; Luo Y(罗阳)4; Huang, Cong1,3; Wang, Ziran1,3; Song GL(宋国立)4; Pan YL(潘昀路)1,3; Zhao XZ(赵学增)1,3; Liu, Shaoqin2,3,5
Department机器人学研究室
Source PublicationSmall
ISSN1613-6810
2021
Volume17Issue:29Pages:1-11
Indexed BySCI ; EI
EI Accession number20212410484857
WOS IDWOS:000659716600001
Contribution Rank2
Funding OrganizationNational Natural Science Foundation of China (Grant Nos.52005137 and 51975145, the China Postdoctoral Science Foundation (Grant No. 2019M661270, the Heilongjiang Postdoctoral Science Foundation (Grant No. LBH-Z19221, and the National Postdoctoral Program for Innovative Talents (Grant No. 20200105).
KeywordCOVID-19 cytokine storm syndrome graphene wearable biosensor wireless and on-site biosensing
Abstract

Abnormal elevated levels of cytokines such as interferon (IFN), interleukin (IL), and tumor necrosis factor (TNF), are considered as one of the prognosis biomarkers for indicating the progression to severe or critical COVID-19. Hence, it is of great significance to develop devices for monitoring their levels in COVID-19 patients, and thus enabling detecting COVID-19 patients that are worsening and to treat them before they become critically ill. Here, an intelligent aptameric dual channel graphene-TWEEN 80 field effect transistor (DGTFET) biosensing device for on-site detection of IFN-γ, TNF-α, and IL-6 within 7 min with limits of detection (LODs) of 476 × 10−15, 608 × 10−15, or 611 × 10−15 m respectively in biofluids is presented. Using the customized Android App together with this intelligent device, asymptomatic or mild COVID-19 patients can have a preliminary self-detection of cytokines and get a warning reminder while the condition starts to deteriorate. Also, the device can be fabricated on flexible substrates toward wearable applications for moderate or even critical COVID-19 cases for consistently monitoring cytokines under different deformations. Hence, the intelligent aptameric DGTFET biosensing device is promising to be used for point-of-care applications for monitoring conditions of COVID-19 patients who are in different situations.

Language英语
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS KeywordFIELD-EFFECT TRANSISTOR ; LABEL-FREE DETECTION ; SELECTIVE DETECTION ; SENSOR ; NANOSENSOR ; SARS-COV-2 ; APTASENSOR ; AFFINITY
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
Funding ProjectNational Natural Science Foundation of China[52005137] ; National Natural Science Foundation of China[51975145] ; China Postdoctoral Science Foundation[2019M661270] ; Heilongjiang Postdoctoral Science Foundation[LBH-Z19221] ; National Postdoctoral Program for Innovative Talents[BX20200105]
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/29054
Collection机器人学研究室
Corresponding AuthorPan YL(潘昀路)
Affiliation1.State Key Laboratory of Robotics and Systems, School of Mechatronics Engineering, Harbin Institute of Technology, Harbin 150001, China
2.School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China
3.Key Laboratory of Micro-systems and Micro-structures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin 150080, China
4.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110169, China
5.State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150080, China
Recommended Citation
GB/T 7714
Hao, Zhuang,Luo Y,Huang, Cong,et al. An Intelligent Graphene-Based Biosensing Device for Cytokine Storm Syndrome Biomarkers Detection in Human Biofluids[J]. Small,2021,17(29):1-11.
APA Hao, Zhuang.,Luo Y.,Huang, Cong.,Wang, Ziran.,Song GL.,...&Liu, Shaoqin.(2021).An Intelligent Graphene-Based Biosensing Device for Cytokine Storm Syndrome Biomarkers Detection in Human Biofluids.Small,17(29),1-11.
MLA Hao, Zhuang,et al."An Intelligent Graphene-Based Biosensing Device for Cytokine Storm Syndrome Biomarkers Detection in Human Biofluids".Small 17.29(2021):1-11.
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