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Detecting CD20-Rituximab specific interactions on lymphoma cells using atomic force microscopy
Li M(李密); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超); Dong ZL(董再励); Li GY(李广勇); Xiao XB(肖秀斌); Zhang WJ(张伟京)
Department机器人学研究室
Source PublicationScience China(Life Sciences)
ISSN1674-7305
2010
Volume53Issue:10Pages:1189–1195
Indexed BySCI
WOS IDWOS:000283120000005
Contribution Rank1
Funding Organizationsupported by the National Natural Science Foundation of China (Grant Nos. 60904095 and 60635040) ; the National High Technology
KeywordAtomic Force Microscopy Single-molecule Force Spectroscopy Cd20 Antigen Rituximab
Abstract

Elucidating the underlying mechanisms of cell physiology is currently an important research topic in life sciences. Atomic force microscopy methods can be used to investigate these molecular mechanisms. In this study, single-molecule force spectroscopy was used to explore the specific recognition between the CD20 antigen and anti-CD20 antibody Rituximab on B lymphoma cells under near-physiological conditions. The CD20-Rituximab specific binding force was measured through tip functionalization.

Language英语
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiology
WOS KeywordMonoclonal-antibody Therapy ; Single-molecule ; Living Cells ; Recognition Events ; Cancer ; Resolution ; Receptor ; Surface ; Localization ; Spectroscopy
WOS Research AreaLife Sciences & Biomedicine - Other Topics
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sia.cn/handle/173321/7339
Collection机器人学研究室
Corresponding AuthorLiu LQ(刘连庆); Xi N(席宁); Zhang WJ(张伟京)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China
2.Department of Electrical and Computer Engineering, Michigan State University, East Lansing 48824, USA
3.Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh 15261, USA
4.Department of Lymphoma Affiliated Hospital of Military Medical Academy of Sciences, Beijing 100071, China
5.Graduate University of Chinese Academy of Sciences, Beijing 100049, China
6.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Recommended Citation
GB/T 7714
Li M,Liu LQ,Xi N,et al. Detecting CD20-Rituximab specific interactions on lymphoma cells using atomic force microscopy[J]. Science China(Life Sciences),2010,53(10):1189–1195.
APA Li M.,Liu LQ.,Xi N.,Wang YC.,Dong ZL.,...&Zhang WJ.(2010).Detecting CD20-Rituximab specific interactions on lymphoma cells using atomic force microscopy.Science China(Life Sciences),53(10),1189–1195.
MLA Li M,et al."Detecting CD20-Rituximab specific interactions on lymphoma cells using atomic force microscopy".Science China(Life Sciences) 53.10(2010):1189–1195.
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