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An experimental study on protein-protein interaction using atomic force microscopy
Li M(李密); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超); Dong ZL(董再励); Li GY(李广勇); Xiao XB(肖秀斌); Zhang WJ(张伟京)
Department机器人学研究室
Conference Name2010 10th IEEE Conference on Nanotechnology, NANO 2010
Conference DateAugust 17-20, 2010
Conference PlaceIlsan, Gyeonggi-Do, Korea
Source Publication2010 10th IEEE Conference on Nanotechnology, NANO 2010
PublisherIEEE Computer Society
Publication PlacePiscataway, NJ, USA
2010
Pages983-986
Indexed ByEI
EI Accession number20110813694582
Contribution Rank1
ISBN978-1-4244-7033-4
KeywordAtomic Force Microscopy Nanotechnology Oncology Physiology
AbstractElucidating the underlying mechanism of the cellular physiological activities at the molecular level is currently an important research topic in life sciences. The invention of the atomic force microscopy (AFM) provided new methods for acquiring new cognition about cellular chemical processes. With the use of AFM, the specific recognition interaction between CD20 antigen and rituximab antibody on B lymphoma cells was explored under near-physiological conditions. The high quality AFM images of B lymphoma cells were acquired and the CD20-rituximab complex binding force was measured by AFM single-molecule force spectroscopy (SMFS). The experimental results provide new insights for understanding the CD20-rituximab specific interaction and lay the foundation for the further investigation of the mechanism of rituximab.
Language英语
Document Type会议论文
Identifierhttp://ir.sia.cn/handle/173321/8567
Collection机器人学研究室
Corresponding AuthorLiu LQ(刘连庆); Xi N(席宁); Zhang WJ(张伟京)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, 110016, China
2.Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, United States
3.Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA 15261, United States
4.Department of Lymphoma, Military Medical Academy of Sciences, Beijing, 100071, China
5.Graduate School of Chinese Academy of Sciences, Beijing, 100049, China
Recommended Citation
GB/T 7714
Li M,Liu LQ,Xi N,et al. An experimental study on protein-protein interaction using atomic force microscopy[C]. Piscataway, NJ, USA:IEEE Computer Society,2010:983-986.
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