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题名: Measuring the molecular force of Burkitt's lymphoma patient cells using AFM
作者: Li M(李密) ; Liu LQ(刘连庆) ; Xi N(席宁) ; Wang YC(王越超) ; Dong ZL(董再励) ; Li GY(李广勇) ; Xiao XB(肖秀斌) ; Zhang WJ(张伟京)
作者部门: 机器人学研究室
会议名称: 4th IEEE International Conference on Nano/Molecular Medicine and Engineering, IEEE NANOMED 2010
会议日期: December 5-9, 2010
会议地点: Hong Kong/Macau, China
会议主办者: IEEE Nanotechnology Council; Chinese International NEMS Society; City University of Hong Kong; The Chinese University of Hong Kong; The University of Hong Kong; University of Macau
会议录: 2010 IEEE International Conference on Nano/Molecular Medicine and Engineering, IEEE NANOMED 2010
会议录出版者: IEEE Computer Society
会议录出版地: Piscataway, NJ
出版日期: 2010
页码: 176-179
收录类别: EI
ISBN号: 9781612841533
关键词: Atomic force microscopy ; Monoclonal antibodies ; Oncology
摘要: The treatment of Non-Hodgkin's lymphoma (NHL) was revolutionized by the approval of rituximab in 1997. Rituximab is a CD20-directed monoclonal antibody (mAb). Despite the great success of rituximab in the treatment of B-cell NHL, the urgent need is to enhance the efficacy due to the markedly variable patient responses. Hence elucidating the molecular mechanisms of rituximab's anti-cancer effect is of great significance. In the past decade the atomic force microscopy (AFM) has proven to be a powerful tool for characterizing the morphological properties and measuring the physiological interaction forces of single cells and single molecules under native conditions. In this work, the AFM single-molecule force spectroscopy(SMFS) was applied to quantitatively measure the CD20-rituximab binding force on Burkitt's lymphoma patient bone marrow cells. The experimental results will facilitate further investigation of the molecular mechanisms of rituximab's anticancer effect. 
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内容类型: 会议论文
URI标识: http://ir.sia.cn/handle/173321/8770
Appears in Collections:机器人学研究室_会议论文

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