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Measuring the molecular force of Burkitt's lymphoma patient cells using AFM
Li M(李密); Liu LQ(刘连庆); Xi N(席宁); Wang YC(王越超); Dong ZL(董再励); Li GY(李广勇); Xiao XB(肖秀斌); Zhang WJ(张伟京)
Department机器人学研究室
Conference Name4th IEEE International Conference on Nano/Molecular Medicine and Engineering, IEEE NANOMED 2010
Conference DateDecember 5-9, 2010
Conference PlaceHong Kong/Macau, China
Author of SourceIEEE Nanotechnology Council; Chinese International NEMS Society; City University of Hong Kong; The Chinese University of Hong Kong; The University of Hong Kong; University of Macau
Source Publication2010 IEEE International Conference on Nano/Molecular Medicine and Engineering, IEEE NANOMED 2010
PublisherIEEE Computer Society
Publication PlacePiscataway, NJ
2010
Pages176-179
Indexed ByEI
EI Accession number20112013993004
Contribution Rank1
ISBN978-1-61284-153-3
KeywordAtomic Force Microscopy Monoclonal Antibodies Oncology
AbstractThe treatment of Non-Hodgkin's lymphoma (NHL) was revolutionized by the approval of rituximab in 1997. Rituximab is a CD20-directed monoclonal antibody (mAb). Despite the great success of rituximab in the treatment of B-cell NHL, the urgent need is to enhance the efficacy due to the markedly variable patient responses. Hence elucidating the molecular mechanisms of rituximab's anti-cancer effect is of great significance. In the past decade the atomic force microscopy (AFM) has proven to be a powerful tool for characterizing the morphological properties and measuring the physiological interaction forces of single cells and single molecules under native conditions. In this work, the AFM single-molecule force spectroscopy(SMFS) was applied to quantitatively measure the CD20-rituximab binding force on Burkitt's lymphoma patient bone marrow cells. The experimental results will facilitate further investigation of the molecular mechanisms of rituximab's anticancer effect. 
Language英语
Document Type会议论文
Identifierhttp://ir.sia.cn/handle/173321/8770
Collection机器人学研究室
Corresponding AuthorLiu LQ(刘连庆); Xi N(席宁); Zhang WJ(张伟京)
Affiliation1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, 110016, China
2.Graduate University, Chinese Academy of Sciences, Beijing, 100049, China
3.Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, United States
4.Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA 15261, United States
5.Department of Lymphoma, Military Medical Academy of Sciences, Beijing, 100071, China
6.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China
Recommended Citation
GB/T 7714
Li M,Liu LQ,Xi N,et al. Measuring the molecular force of Burkitt's lymphoma patient cells using AFM[C]//IEEE Nanotechnology Council; Chinese International NEMS Society; City University of Hong Kong; The Chinese University of Hong Kong; The University of Hong Kong; University of Macau. Piscataway, NJ:IEEE Computer Society,2010:176-179.
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